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Key Takeaway: Semaglutide is a hormone mimic that works by signaling the brain to feel full sooner and stay full longer, while simultaneously stabilizing blood sugar levels

That signal is what separates people who lose mostly fat on these drugs from people who lose muscle along with it

Combined with any of the semaglutide-related risk factors, smoking creates a multiplicative rather than additive increase in clot risk

Their provider recommends adding semaglutide to address the weight gain

This divergence coincides with the CVS formulary change and is further reflected in first-time prescribing patterns

The metabolic coordination that GLP-1 is designed to provide gets truncated before it can fully execute